DeCS Server - List Exact Term

Search on:	MULTIPLE ENDOCRINE NEOPLASIA TYPE 1
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DeCS

Descriptor English:

Multiple Endocrine Neoplasia Type 1

Descriptor Spanish:

Neoplasia Endocrina Múltiple Tipo 1

Descriptor Portuguese:

Neoplasia Endócrina Múltipla Tipo 1

Synonyms English:

MEN 1
Neoplasia, Multiple Endocrine Type 1
Neoplasms, Multiple Endocrine Type 1
Wermer Syndrome

Tree Number:

Definition English:

A form of multiple endocrine neoplasia that is characterized by the combined occurrence of tumors in the PARATHYROID GLANDS, the PITUITARY GLAND, and the PANCREATIC ISLETS. The resulting clinical signs include HYPERPARATHYROIDISM; HYPERCALCEMIA; HYPERPROLACTINEMIA; CUSHING DISEASE; GASTRINOMA; and ZOLLINGER-ELLISON SYNDROME. This disease is due to loss-of-function of the MEN1 gene, a tumor suppressor gene (GENES, TUMOR SUPPRESSOR) on CHROMOSOME 11 (Locus: 11q13).

Indexing Annotation English:

coordinate IM with specific endocrine/neoplasm pre-coordinates (IM) + specific histological type (IM) if pertinent

History Note English:

95; MEA I, MEN I, & WERMER SYNDROME were see NEOPLASMS, MULTIPLE ENDOCRINE 1983-94

Allowable Qualifiers English:

Record Number:

32134

Unique Identifier:

D018761

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